Need advice - fishing off Changes

As we've been in the Chesapeake Bay, I've been wondering if anyone has fished off their boat in the Bay or in the ICW and if they have, what they've used.  We have a Cuban Reel with 80# line and the lures to catch Tuna and Mahi Mahi, but don't know what is needed - or if there are fish to catch while we are motoring or sailing in more protected waters.   I would appreciate any information that someone could provide either to my email or as a comment on the blog.  BTW we don't have any other fishing equipment on the boat besides mentioned above.  Thanks!